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Alternative name
ATG6, Beclin 1, beclin 1, autophagy related, beclin1, BECN1, GT197, Protein GT197, VPS30 antibody
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Catalog
A000860
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,IHC,IP,WB,IF
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PurificationImmunogen affinity purified
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Immunogenbeclin 1, autophagy related
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IHCImmunohistochemistry of paraffin-embedded human colon cancer using A000860(Beclin 1 antibody) at dilution of 1:50
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Western BlotMDA-MB-453s cells were subjected to SDS PAGE followed by western blot with A000860( Beclin 1 Antibody) at dilution of 1:1000
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalBeclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
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Gene nameBECN1
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Uniprot IDQ14457?
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Calculated M.W.60kDa
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Observed M.W.60 kDa
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