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Alternative name
FLJ33531, IL 1RAcPIP, toll interacting protein, TOLLIP antibody
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Catalog
A008854
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IF
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PurificationImmunogen affinity purified
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Immunogentoll interacting protein
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IHCImmunohistochemistry of paraffin-embedded human gliomas using A008854(TOLLIP antibody) at dilution of 1:100
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Western BlotPC-3 cells were subjected to SDS PAGE followed by western blot with A008854(TOLLIP antibody) at dilution of 1:500
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalComponent of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin- ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).
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Gene nameTOLLIP
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Uniprot IDQ9H0E2
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Observed M.W.30 kDa
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