-
Alternative name
ANKTM1, TRPA1 antibody
-
Catalog
A009013
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman
-
Applications Tested/SuitableELISA,WB
-
PurificationImmunogen affinity purified
-
Immunogentransient receptor potential cation channel, subfamily A, member 1
-
Western BlotSH-SY5Y cells were subjected to SDS PAGE followed by western blot with A009013(TRPA1 antibody) at dilution of 1:500
-
Recommended dilutionWB:1:500-1:5000
-
Product Description specificalReceptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).
-
Gene nameTRPA1
-
Uniprot IDO75762
-
Calculated M.W.127kDa
-
Observed M.W.120-130 kDa
-