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Alternative name
ESCRT I complex subunit TSG101, TSG10, TSG101, tumor susceptibility gene 101, VPS23 antibody
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Catalog
A009040
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IF,IP,FC
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PurificationImmunogen affinity purified
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Immunogentumor susceptibility gene 101
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IHCImmunohistochemistry of paraffin-embedded human colon cancer tissue slide using A009040( TSG101 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A009040(TSG101 antibody) at dilution of 1:500
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Recommended dilutionWB:1:200-1:2000；IP:1:200-1:2000；IHC:1:100-1:400；IF:1:10-1:100
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Product Description specificalComponent of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
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Gene nameTSG101
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Uniprot IDQ99816
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Calculated M.W.46kDa
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Observed M.W.46 kDa
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