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Alternative name
ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP, UMOD, uromodulin antibody
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Catalog
A009294
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IP
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PurificationImmunogen affinity purified
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Immunogenuromodulin
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IHCImmunohistochemistry of paraffin-embedded human kidney using A009294(UMOD antibody) at dilution of 1:50
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Western Blothuman heart tissue were subjected to SDS PAGE followed by western blot with A009294(UMOD antibody) at dilution of 1:400
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Recommended dilutionWB : 1:200-1:2000;IHC:1:20-1:200;IP：1:200-1:2000
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Product Description specificalUromodulin, also known as THP (Tamm-Horsfall glycoprotein), is the most abundant protein excreted in the urine under physiological conditions. Uromodulin is synthesized by kidney and localizes in cells lining the ascending limb of Henle and distal convoluted tubule. Uromodulin has been linked to water/electrolyte balance and to kidney innate immunity. Also, studies in knockout mice demonstrated that it has a protective role against urinary tract infections and renal stone formation. Mutations in the gene encoding uromodulin lead to rare autosomal dominant diseases, collectively referred to as uromodulin-associated kidney diseases. (PMID: 21654721)
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Gene nameUMOD
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locationcell membrane,ecreted
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Uniprot IDP07911
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Calculated M.W.70kDa,Observed 55kDa
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Observed M.W.55-75 kDa
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