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Alternative name
Deubiquitinating enzyme 21, Ubiquitin thiolesterase 21, USP16, USP21, USP23 antibody
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Catalog
A009318
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenubiquitin specific peptidase 21
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IHCImmunohistochemistry of paraffin-embedded human heart tissue slide using A009318( USP21 Antibody) at dilution of 1:50
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Western BlotRAW 264.7 cells were subjected to SDS PAGE followed by western blot with A009318( USP21 Antibody) at dilution of 1:600
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Recommended dilutionWB : 1:200-1:2000;IHC:1:20-1:200
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Product Description specificalDeubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909).
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Gene nameUSP21
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locationCytoplasm,Nucleus
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Uniprot IDQ9UK80
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Calculated M.W.63kDa
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Observed M.W.63 kDa
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