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Alternative name
Deubiquitinating enzyme 37, KIAA1594, Ubiquitin thiolesterase 37, USP37 antibody
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Catalog
A009330
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB
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PurificationImmunogen affinity purified
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Immunogenubiquitin specific peptidase 37
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Western BlotHEK-293 cells were subjected to SDS PAGE followed by western blot with A009330(USP37 antibody) at dilution of 1:500
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Recommended dilutionWB : 1:500-1:5000;IP:1：200-1：2000
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Product Description specificalDeubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'- linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2).
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Gene nameUSP37
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Uniprot IDQ86T82
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Calculated M.W.110kDa，70kDa
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Observed M.W.110 kDa
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