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Alternative name
HRCA1, Protein G7, pVHL, RCA1, VHL, VHL1, Von Hippe-Lindau antibody
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Catalog
A009402
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,IF,IHC
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PurificationImmunogen affinity purified
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Immunogenvon Hippel-Lindau tumor suppressor
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IHCImmunohistochemical of paraffin-embedded human kidney using A009402(VHL antibody) at dilution of 1:50
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Recommended dilutionIF:1:10-1:100;IHC:1:20-1:200
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Product Description specificalInvolved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
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Gene nameVHL
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locationCytoplasm,Membrane,Nucleus
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Uniprot IDP40337
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Calculated M.W.20kDa
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