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Alternative name
FLJ22395, FLJ23187, hVPS33A, VPS33A antibody
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Catalog
A009435
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB
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PurificationImmunogen affinity purified
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Immunogenvacuolar protein sorting 33 homolog A (S. cerevisiae)
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Western Blothuman brain tissue were subjected to SDS PAGE followed by western blot with A009435(VPS33A antibody) at dilution of 1:500
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Recommended dilutionWB :1:500-1:5000;IP:1:200-1:2000
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Product Description specificalPlays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).
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Gene nameVPS33A
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locationCytoplasmic vesicle,Endosome,Lysosome,Membrane
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Uniprot IDQ96AX1
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Calculated M.W.68kDa
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Observed M.W.68 kDa
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