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Alternative name
F8VWF, von Willebrand antigen II, von Willebrand factor, VWD, VWF antibody
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Catalog
A009466
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenvon Willebrand factor
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IHCImmunohistochemistry of paraffin-embedded human tonsillitis tissue slide using A009466( VWF, VWFpp Antibody) at dilution of 1:200
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Western BlotJurkat cells were subjected to SDS PAGE followed by western blot with A009466(VWF, VWFpp antibody) at dilution of 1:500
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Recommended dilutionWB : 1:200-1:2000；IHC:1:100-1:400
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Product Description specificalVon Willebrand factor (vWF) is a large multimeric glycoprotein that is crucial to the hemostasis process. It supports platelet adhesion and carries factor VIII (FVIII). Deficiency of vWF results in von Willebrand disease (vWD), a common inherited bleeding disorder. The pre-pro-vWF is comprised of 2,813 amino acids (aa) which encompass a 22-aa signal peptide, a 741-aa large propeptide (vWF propeptide, vWFpp, also called von Willebrand antigen II) and 2,050 aa making up the mature vWF. The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules. This antibody raised against the N-terminal region (residues 56-256 aa) of pre-pro-vWF recognizes von Willebrand antigen 2 (75-83 kDa) and pro-vWF (309-320 kDa). (PMID: 9759493; 12067899; 22452980; 8874191)
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Gene nameVWF
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locationExtracellular matrix,Secreted
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Uniprot IDP04275
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Calculated M.W.309kDa,observed 70kDa，309kDa
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Observed M.W.309-320 kDa,75-100 kDa
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