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Alternative name
ALFY, Autophagy linked FYVE protein, KIAA0993, WDFY3, ZFYVE25 antibody
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Catalog
A009479
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,IHC
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PurificationImmunogen affinity purified
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ImmunogenWD repeat and FYVE domain containing 3
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Western BlotImmunohistochemical of paraffin-embedded human breast cancer using A009479(WDFY3 antibody) at dilution of 1:50
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Recommended dilutionIHC:1:20-1:200
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Product Description specificalRequired for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.
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Gene nameWDFY3
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locationCytoplasm,Membrane,Nucleus
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Uniprot IDQ8IZQ1
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