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Alternative name
Actin interacting protein 1, AIP1, NORI 1, WD repeat containing protein 1, WD repeat domain 1, WDR1 antibody
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Catalog
A009481
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,IHC,IP,WB
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PurificationImmunogen affinity purified
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ImmunogenWD repeat domain 1
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IHCImmunohistochemistry of paraffin-embedded human testis using A009481(WDR1 antibody) at dilution of 1:100
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Western Blotrat skeletal muscle tissue were subjected to SDS PAGE followed by western blot with A009481( WDR1 Antibody) at dilution of 1:600
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Recommended dilutionWB : 1:200-1:2000;IP:1:200-1:2000;IHC:1:20-1:200
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Product Description specificalInduces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).
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Gene nameWDR1
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locationCell junction,Cell projection,Cytoplasm,Cytoskeleton
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Uniprot IDO75083
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Calculated M.W.66kDa
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Observed M.W.66-70 kDa
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