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Alternative name
C16orf21, DKFZp434F054, JFP7, WD repeat domain 24, WDR24 antibody
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Catalog
A009488
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IHC,IF
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PurificationImmunogen affinity purified
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ImmunogenWD repeat domain 24
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IHCImmunohistochemistry of paraffin-embedded human ovary using A009488(WDR24 antibody) at dilution of 1:50
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A009488(WDR24 antibody) at dilution of 1:500
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Recommended dilutionWB : 1:500-1:5000;IP:1:200-1:2000;IF:1:10-1:100;IHC:1:20-1:200
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Product Description specificalAs a component of the GATOR subcomplex GATOR2, functions as an activator of the amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:27166823). Inhibits the GATOR1 subcomplex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway (PubMed:23723238). Functions downstream of and is regulated by amino acid sensors like SESN2 (PubMed:26449471, PubMed:26586190). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).
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Gene nameWDR24
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locationCytoplasm,nuleus
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Uniprot IDQ96S15
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Calculated M.W.102kDa
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Observed M.W.102 kDa,88 kDa
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