-
Alternative name
WIPI2, FLJ14217, WIPI 2, WIPI49 like protein 2, FLJ42984 antibody
-
Catalog
A009513
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman, Mouse
-
Applications Tested/SuitableELISA,WB
-
PurificationImmunogen affinity purified
-
ImmunogenWD repeat domain, phosphoinositide interacting 2
-
Western Blothuman placenta tissue were subjected to SDS PAGE followed by western blot with A009513(WIPI2 antibody) at dilution of 1:200
-
Recommended dilutionWB : 1:200-1:2000
-
Product Description specificalEarly component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). May bind PtdIns3P. _x000D_Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.
-
Gene nameWIPI2
-
Uniprot IDQ9Y4P8
-
Calculated M.W.49kDa
-
Observed M.W.49kd
-