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Alternative name
Exp7, exportin 7, KIAA0745, Ran binding protein 16, RANBP16, XPO7 antibody
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Catalog
A009551
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB
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PurificationImmunogen affinity purified
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Immunogenexportin 7
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Western BlotK-562 cells were subjected to SDS PAGE followed by western blot with A009551(XPO7 antibody) at dilution of 1:300
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Recommended dilutionWB:1:500-1:5000
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Product Description specificalMediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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Gene nameXPO7
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locationCytoplasm,Nuclear pore complex,Nucleus
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Uniprot IDQ9UIA9
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Calculated M.W.124kDa,Observed 100kDa
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Observed M.W.100-110kd
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