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Alternative name
DKFZp781P0919, DNA repair protein XRCC2, XRCC2 antibody
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Catalog
A009553
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB
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PurificationImmunogen affinity purified
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ImmunogenX-ray repair complementing defective repair in Chinese hamster cells 2
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Western BlotK-562 cells were subjected to SDS PAGE followed by western blot with A009553( XRCC2 Antibody) at dilution of 1:600
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Recommended dilutionWB:1:200-1:2000;IP:1:200-1:2000
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Product Description specificalInvolved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
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Gene nameXRCC2
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locationCytoplasm,Cytoskeleton,Nucleus
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Uniprot IDO43543
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Calculated M.W.32kDa,Observed 40kDa
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Observed M.W.35-40 kDa
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