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Alternative name
5 3 exoribonuclease 1, 5' 3' exoribonuclease 1, DKFZp434P0721, DKFZp686B22225, DKFZp686F19113, FLJ41903, SEP1, XRN1 antibody
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Catalog
A009556
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IHC,IF
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PurificationImmunogen affinity purified
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Immunogen5'-3' exoribonuclease 1
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IHCImmunohistochemistry of paraffin-embedded human heart slide using A009556( XRN1 Antibody) at dilution of 1:50
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A009556(XRN1 antibody) at dilution of 1:600
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Recommended dilutionWB:1:200-1:2000;IHC:1:20-1:200;IF:1:20-1:200
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Product Description specificalMajor 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).
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Gene nameXRN1
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locationCytoplasm
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Uniprot IDQ8IZH2
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Calculated M.W.192kDa
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Observed M.W.175 kDa
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