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Alternative name
XRN2, DHM1 like protein, DHP protein, 5' 3' exoribonuclease 2, 5 3 exoribonuclease 2 antibody
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Catalog
A009557
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB
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PurificationImmunogen affinity purified
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Immunogen5'-3' exoribonuclease 2
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Western BlotHEK-293 cells were subjected to SDS PAGE followed by western blot with A009557(XRN2 antibody) at dilution of 1:200
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Recommended dilutionWB:1:200-1:1000
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Product Description specificalPossesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).
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Gene nameXRN2
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Uniprot IDQ9H0D6
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Calculated M.W.100kDa,Observed 100kDa,55kDa
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Observed M.W.104kd
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