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Alternative name
ZBTB38, FLJ31131, FLJ35036, CIBZ, FLJ22332 antibody
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Catalog
A009593
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenzinc finger and BTB domain containing 38
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IHCImmunohistochemistry of paraffin-embedded human testis using A009593(ZBTB38 antibody) at dilution of 1:50
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Western BlotHepG2 cells were subjected to SDS PAGE followed by western blot with A009593(ZBTB38 antibody) at dilution of 1:1000
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Recommended dilutionWB:1:500-1:5000;IHC:1:20-1:200
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Product Description specificalTranscriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl- CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA- replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).
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Gene nameZBTB38
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locationChromosome,Nucleus
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Uniprot IDQ8NAP3
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Calculated M.W.134kDa
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Observed M.W.134kd
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