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Human CRLF2 ELISA Kit

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  • Alternative name

    Human Cytokine receptor-like 2 ELISA Kit;Human IL-XR ELISA Kit;Human thymic stromal lymphopoietin protein receptor ELISA Kit;Human TSLP receptor ELISA Kit;Human CRL2 ELISA Kit;Human ILXR ELISA Kit;Human TSLPR ELISA Kit;Human CRLF2Y ELISA Kit;Human cytokine receptor-like factor 2 ELISA Kit;Human cytokine receptor CRL2 precusor ELISA Kit;Human thymic stromal-derived lymphopoietin receptor ELISA Kit;
  • Catalog
    E010230
  • species
    Human
  • GeneCRLF2
  • SpecificityNatural and recombinant human CRLF2
  • SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
  • Sensitivity< 10pg/ml
  • Intended UseHuman CRLF2 ELISA Kit allows for the in vitro quantitative determination of CRLF2 , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
  • StorageStore the whole ELISA kit at 4℃
  • Product Description
    specifical    Principle of the assay: human CRLF2 ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. A monoclonal antibody from mouse specific for CRLF2 has been precoated onto 96-well plates. Standards(NSO, G25-K231) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for CRLF2 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the human CRLF2 amount of sample captured in plate. Background: Cytokine receptor-like factor 2, also known as TSLPR or CRL2, is a protein that in humans is encoded by the CRLF2 gene. It is mapped to Xp22.33. The protein encoded by this gene is a receptor for thymic stromal lymphopoietin(TSLP). Together with the interleukin 7 receptor(IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. In addition to it, it has been found that rearrangement of CRLF2 and JAK mutation together contribute to leukemogenesis in B-progenitor ALL.
  • Human Cytokine receptor-like factor 2 Protein information
  • Uniprot ID CRLF2_HUMAN
  • Uniprot AC Q9HC73; J3QKD1; Q5G7M1; Q9H5R3;
  • UniGene Hs.287729;
  • GeneID 64109
  • KEGG hsa:64109;
  • Human Cytokine receptor-like factor 2 Protein SEQUENCE

  • SEQUENCE 371 AA; 42013 MW; DEA53814758B69E4 CRC64;

    MGRLVLLWGA AVFLLGGWMA LGQGGAAEGV QIQIIYFNLE TVQVTWNASK

    YSRTNLTFHY RFNGDEAYDQ CTNYLLQEGH TSGCLLDAEQ RDDILYFSIR

    NGTHPVFTAS RWMVYYLKPS SPKHVRFSWH QDAVTVTCSD LSYGDLLYEV

    QYRSPFDTEW QSKQENTCNV TIEGLDAEKC YSFWVRVKAM EDVYGPDTYP

    SDWSEVTCWQ RGEIRDACAE TPTPPKPKLS KFILISSLAI LLMVSLLLLS

    LWKLWRVKKF LIPSVPDPKS IFPGLFEIHQ GNFQEWITDT QNVAHLHKMA

    GAEQESGPEE PLVVQLAKTE AESPRMLDPQ TEEKEASGGS LQLPHQPLQG

    GDVVTIGGFT FVMNDRSYVA L

  • UCSC uc022brs.3; human. [Q9HC73-1];



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