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Alternative name
CDC39, KIAA1007, NOT1 antibody
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Catalog
A001805
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,IHC,WB,IP
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PurificationImmunogen affinity purified
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ImmunogenCCR4-NOT transcription complex, subunit 1
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IHCImmunohistochemistry of paraffin-embedded human heart tissue slide using A001805( CNOT1 Antibody) at dilution of 1:200
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Western Blothuman brain tissue were subjected to SDS PAGE followed by western blot with A001805(CNOT1 antibody) at dilution of 1:800
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalScaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.
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Gene nameCNOT1
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Uniprot IDA5YKK6
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Observed M.W.240-250 kDa,174 kDa
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