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Alternative name
Absent in melanoma 2, AIM2, PYHIN4 antibody
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Catalog
A000238
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenabsent in melanoma 2
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IHCImmunohistochemistry of paraffin-embedded human testis using A000238(AIM2 antibody) at dilution of 1:100
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Western BlotK-562 cells were subjected to SDS PAGE followed by western blot with A000238(AIM2 antibody) at dilution of 1:1000
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Recommended dilutionWB :1:500-1:5000;IHC:1:20-200
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Product Description specificalInvolved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
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Gene nameAIM2
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locationCytoplasm,Nucleus
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Uniprot IDO14862
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Calculated M.W.40kDa
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Observed M.W.40-45 kDa
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