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Alternative name
ABHD2, Protein PHPS1 2, HS1 2, Lung alpha/beta hydrolase 2, LABH2 antibody
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Catalog
A000049
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenabhydrolase domain containing 2
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IHCImmunohistochemistry of paraffin-embedded human spleen using A000049(ABHD2 antibody) at dilution of 1:100
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Western BlotHEK-293 cells were subjected to SDS PAGE followed by western blot with A000049(ABHD2 antibody) at dilution of 1:500
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Recommended dilutionWB :1:500-1:5000;IHC:1:20-1:200
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Product Description specificalProgesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).
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Gene nameABHD2
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locationMembrane
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Uniprot IDP08910
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Calculated M.W.48kDa
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Observed M.W.48 kDa
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