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Alternative name
KIAA0439, NEDL3 antibody
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Catalog
A005646
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenneural precursor cell expressed, developmentally down-regulated 4-like
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IHCImmunohistochemistry of paraffin-embedded human prostate cancer using A005646(NEDD4L antibody) at dilution of 1:100
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Western BlotK-562 cells were subjected to SDS PAGE followed by western blot with A005646(NEDD4L antibody) at dilution of 1:500
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalE3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
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Gene nameNEDD4L
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Uniprot IDQ96PU5
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Observed M.W.112 kDa,125 kDa
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