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Alternative name
PAD1, POH1, PSMD14, rpn11 antibody
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Catalog
A006886
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenproteasome (prosome, macropain) 26S subunit, non-ATPase, 14
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IHCImmunohistochemistry of paraffin-embedded human colon cancer using A006886(PSMD14 antibody) at dilution of 1:50
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Western Blothuman heart tissue were subjected to SDS PAGE followed by western blot with A006886(PSMD14 antibody) at dilution of 1:400
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Recommended dilutionWB:1:200-1:2000;IHC:1:20-1:200
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Product Description specificalMetalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
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Uniprot IDO00487
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Calculated M.W.35kDa
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