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Human GHR ELISA Kit

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  • Alternative name

    Human GH receptor ELISA Kit;Human somatotropin receptor ELISA Kit;Human GH-binding protein ELISA Kit;Human GHBP ELISA Kit;Human Serum-binding protein ELISA Kit;Human GHIP ELISA Kit;Human growth hormone receptor ELISA Kit;Human growth hormone binding protein ELISA Kit;Human serum binding protein ELISA Kit;
  • Catalog
    E016394
  • species
    Human
  • GeneGHR
  • SpecificityNatural and recombinant Human GHR
  • SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
  • Sensitivity Intra-assay Precision Intra-Assay Precision (Precision within an assay) Three samples of kn
  • Intended UseHuman GHR ELISA Kit allows for the in vitro quantitative determination of GHR , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
  • StorageStore the whole ELISA kit at 4℃
  • Product Description
    specifical    Principle of the Assay: Human GHR ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. A monoclonal antibody from mouse specific for GHR has been precoated onto 96-well plates. Standards(Expression system for standard: NSO; Immunogen sequence: A27-Y264) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for GHR is added subsequently and then followed by washing with PBS or TBS buffer. Avidin- Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the Human GHR amount of sample captured in plate. Background/Introduction: Growth hormone receptor is a protein that in humans is encoded by the GHR gene. It is mapped to chromosome 5p13.1-p12. This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization (the receptor may however also exist as a pre-assembled non-functional dimer) and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature (proportional dwarfism).
  • Human Growth hormone-binding protein Protein information
  • Uniprot ID GHR_HUMAN
  • Uniprot AC P10912; Q9HCX2;
  • UniGene Hs.125180; Hs.684632; Hs.688223;
  • GeneID 2690
  • KEGG hsa:2690;
  • Human Growth hormone-binding protein Protein SEQUENCE

  • SEQUENCE 638 AA; 71500 MW; EAF77EADE4787822 CRC64;

    MDLWQLLLTL ALAGSSDAFS GSEATAAILS RAPWSLQSVN PGLKTNSSKE

    PKFTKCRSPE RETFSCHWTD EVHHGTKNLG PIQLFYTRRN TQEWTQEWKE

    CPDYVSAGEN SCYFNSSFTS IWIPYCIKLT SNGGTVDEKC FSVDEIVQPD

    PPIALNWTLL NVSLTGIHAD IQVRWEAPRN ADIQKGWMVL EYELQYKEVN

    ETKWKMMDPI LTTSVPVYSL KVDKEYEVRV RSKQRNSGNY GEFSEVLYVT

    LPQMSQFTCE EDFYFPWLLI IIFGIFGLTV MLFVFLFSKQ QRIKMLILPP

    VPVPKIKGID PDLLKEGKLE EVNTILAIHD SYKPEFHSDD SWVEFIELDI

    DEPDEKTEES DTDRLLSSDH EKSHSNLGVK DGDSGRTSCC EPDILETDFN

    ANDIHEGTSE VAQPQRLKGE ADLLCLDQKN QNNSPYHDAC PATQQPSVIQ

    AEKNKPQPLP TEGAESTHQA AHIQLSNPSS LSNIDFYAQV SDITPAGSVV

    LSPGQKNKAG MSQCDMHPEM VSLCQENFLM DNAYFCEADA KKCIPVAPHI

    KVESHIQPSL NQEDIYITTE SLTTAAGRPG TGEHVPGSEM PVPDYTSIHI

    VQSPQGLILN ATALPLPDKE FLSSCGYVST DQLNKIMP

  • UCSC uc003jmt.4; human. [P10912-1];



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