Cell's latest report, the American scientists at baylor college of medicine study found that a can directly regulate blood sugar and insulin hormone, this hormone secreted by the white fat, scientists will therefore he called Asprosin (when we translate it as white fat element).
Neonatal Progeroid Syndrome (NPS)is a rare genetic disease, patients showed retardation, subcutaneous fat is reduced, the symptom such as abnormal blood lipid level of atherosclerosis, the vast majority of basic early death due to cardiovascular patients, life no more than 20 years old.
Chopra and his team found that this energy metabolic disorder was associated with the hormone aspeosin in the study of the pathogenesis of the disease.
Asprosin shear is fibrillar precursor protein C end product, and premature aging disease patient FBN1 fibrils protein genes encoding truncated mutation, the gene transcription of mRNA for body protection (nonsense mediated mRNA degradation, nonsense - mediated decay, NMD) and degradation, the expression of asprosin quantity is far below average.
They found that the gene FBN1 had the highest expression in adipose tissue, while fat as an important secretory organ, asprosin was mainly secreted by adipose tissue.
The concentration of asprosin in the body was associated with eating, and the asprosin concentration decreased and the fasting increased.
Asprosin can have an effect on blood sugar and insulin levels.
After injecting asprosin into the mice, the blood sugar began to rise, and then the insulin concentration went up, and the blood sugar was restored after one hour of injection.
And constant injected mice with asprosin or use adenoviruses that mice sustained expression of endogenous asprosin, glucose and insulin can be found that mice are to maintain a high level, and other hormones such as glucagon, catechins, etc are not affected.
The symptoms are consistent with type 2 diabetes.
The study of the mechanism of action of asprosin shows that in the body, asprosin targeted transport to the liver and liver cell surface receptors and specificity, activate the G protein - cAMP - PKA signaling pathways, regulating the liver cells release glucose into the blood, asprosin dosage is related to the activation of this pathway is also positively related to the glucose release quantity.
In patients with progeria, the lack of Asprosin can not complete the procedure, usually shown as low levels of blood sugar and insulin.
In contrast, obese/diabetic patients with high blood glucose and high insulin levels tend to have higher levels of asprosin.
Chopra and his team hope to suppress asprosin by blocking the immune system.
They injected the antibodies of asprosin into the abdominal cavity of the diabetic model mice, and the antibody was combined with asprosin to reduce the asprosin level to suppress asprosin, blocking the effect of the PKA signaling pathway.
The results showed that a single dose of antibodies could reduce blood glucose and insulin levels in mice, and the mice would be able to fully cure their insulin resistance if they were given a long-term injection of antibodies.
The discovery of the hormone contributes to the study of diabetes mellitus and provides new ideas and methods for diabetes treatment, and it is expected to be a new target for diabetes treatment.
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