The application and prospect of new hormone asprosin can increase the release of glycogen in glycogen by the G protein cAMP - PKA signaling pathway


2017-08-21 20:14:48 GMT+0800

Asprosin A new hormone, produced by fat layer and secretion, is A former spliceosome fibrillar protein C end, is A kind of rapid response of plasma protein, it can be used in the liver protein kinase A cAMP, the second messenger system stimulation.
Experiments show that the trace asprosin ten minutes after injection in rats observed that the increase of cAMP and PKA, in addition, the heterogeneous trimer of G protein inhibitors can suramin blockade asprosin influence on release and PKA activation of hepatic glycogen, and use the competitive of cAMP and PKA antagonist objects can also be blocking asprosin adjust the release of the liver glycogen, all of these results to prove in a living organism, or a test tube, asprosin can through the cAMP, the G protein - the release of PKA signaling pathways to increase liver glycogen.


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