A new type of protein hormone has been found to regulate the balance of glucose in the body.
The newly discovered hormone is called Asprosin, which is produced by white fat and is very small in the body.
If asprosin is missing, it can be accompanied by a decrease in plasma insulin, leading to local metabolic abnormalities.
Asprosin content is less, but its role is cannot be ignored, when it enters the liver, activation of G protein - cAMP - PKA, make liver release glucose into the bloodstream, Asprosin effective combination of liver cells and automatically increase the plasma glucose.
The researchers used single-dose recombination Asprosin to boost blood sugar and insulin in mice.
They used heterotopic super-long FBN1 to transfer organs to the ideal adenovirus, whose main purpose was to promote the synthesis of profibrillin and the secretion of asprosin.
This strategy shows that profibrillin protein can stabilize excess expression in the liver and plasma asprosin levels are twice as high.
The second strategy is to inject the bacteria in the daily situation with the asprosin or recombinant expression of GFP as the control factor.
In 10 days, the rat plasma asprosines increased continuously or intermittently, and the rats were fasting for two hours and 40 minutes and the results resulted in elevated blood sugar and insulin.
The increase in blood sugar and insulin was enough to prove that the bacterial recombinant expression asprosin was able to maintain normal biological activity.
In order to understand the emergency response, the researchers have been fasting and 2 hours and 40 minutes before the mice injected with the single restructuring asprosin, at the same time in a 15,30,45,60 minutes each measured blood sugar concentration, banned feeding rats during the experiments.
Asprosin can cause blood sugar levels to spike immediately.
The compensatory insulin results exceeded normal levels after 60 minutes.
The same results were found for mice injected with asprosin overnight.
Although blood sugar is slowed down by substrate consumption.
This phenomenon indicates that the liver is the main body that synthesizes asprosin.
The liver plays the role of storing glucose and releasing energy.
What's interesting is that the breakdown of hormone asprosin doesn't work.
Mice with asprosin-blocking antibodies to insulin resistance were able to lower the level of insulin in the blood.
Thus reducing asprosin levels may be a new way to treat type 2 diabetes.
The study found that in an empty stomach, people and mice had a spike in blood concentrations.
If the mice were given extra asprosin, the levels of glucose and insulin in the blood were significantly increased.
The conclusion is that asprosin can bind to liver cells and cause glucose release.